In April of 2019, NASADAD sent an inquiry to the Single State Agencies for alcohol and other drug services requesting information on how they were using the State Targeted Response (STR) and State Opioid Response (SOR) grants to address the opioid crisis in their States. The results of the inquiry were summarized into State-specific profiles highlighting prevention, treatment, overdose reversal, and recovery support efforts. Below are brief analyses of the most common ways States have used STR and SOR funds for prevention, treatment, overdose reversal, recovery support, and examples of innovative State initiatives.